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Macrophage MMP10 Regulates TLR7-Mediated Tolerance
Using an in vivo model of tolerance to TLR7-induced skin inflammation, we found a critical role for macrophage-derived MMP10 in mediating immune hypo-responsiveness. Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1β, IL6, CXCL1) and neu...
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| Pubblicato in: | Front Immunol |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6288447/ https://ncbi.nlm.nih.gov/pubmed/30564235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02817 |
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