Macrophage MMP10 Regulates TLR7-Mediated Tolerance

Using an in vivo model of tolerance to TLR7-induced skin inflammation, we found a critical role for macrophage-derived MMP10 in mediating immune hypo-responsiveness. Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1β, IL6, CXCL1) and neu...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Rohani, Maryam G., Dimitrova, Elizabeth, Beppu, Andrew, Wang, Ying, Jefferies, Caroline A., Parks, William C.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288447/
https://ncbi.nlm.nih.gov/pubmed/30564235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02817
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