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Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens
Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)–producing Bregs maintain tolerance to islet autoantigens, and t...
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Publicado no: | Diabetes |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Diabetes Association
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4274804/ https://ncbi.nlm.nih.gov/pubmed/25187361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1639 |
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