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Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens

Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)–producing Bregs maintain tolerance to islet autoantigens, and t...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kleffel, Sonja, Vergani, Andrea, Tezza, Sara, Ben Nasr, Moufida, Niewczas, Monika A., Wong, Susan, Bassi, Roberto, D’Addio, Francesca, Schatton, Tobias, Abdi, Reza, Atkinson, Mark, Sayegh, Mohamed H., Wen, Li, Wasserfall, Clive H., O’Connor, Kevin C., Fiorina, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274804/
https://ncbi.nlm.nih.gov/pubmed/25187361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1639
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