Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens

Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)–producing Bregs maintain tolerance to islet autoantigens, and t...

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Publicado en:Diabetes
Autores principales: Kleffel, Sonja, Vergani, Andrea, Tezza, Sara, Ben Nasr, Moufida, Niewczas, Monika A., Wong, Susan, Bassi, Roberto, D’Addio, Francesca, Schatton, Tobias, Abdi, Reza, Atkinson, Mark, Sayegh, Mohamed H., Wen, Li, Wasserfall, Clive H., O’Connor, Kevin C., Fiorina, Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2015
Materias:
Immunology and Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274804/
https://ncbi.nlm.nih.gov/pubmed/25187361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1639
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