Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens

Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)–producing Bregs maintain tolerance to islet autoantigens, and t...

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發表在:Diabetes
Main Authors: Kleffel, Sonja, Vergani, Andrea, Tezza, Sara, Ben Nasr, Moufida, Niewczas, Monika A., Wong, Susan, Bassi, Roberto, D’Addio, Francesca, Schatton, Tobias, Abdi, Reza, Atkinson, Mark, Sayegh, Mohamed H., Wen, Li, Wasserfall, Clive H., O’Connor, Kevin C., Fiorina, Paolo
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2015
主題:
Immunology and Transplantation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274804/
https://ncbi.nlm.nih.gov/pubmed/25187361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1639
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