Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens

Impaired regulatory B cell (Breg) responses are associated with several autoimmune diseases in humans; however, the role of Bregs in type 1 diabetes (T1D) remains unclear. We hypothesized that naturally occurring, interleukin-10 (IL-10)–producing Bregs maintain tolerance to islet autoantigens, and t...

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Опубликовано в: :Diabetes
Главные авторы: Kleffel, Sonja, Vergani, Andrea, Tezza, Sara, Ben Nasr, Moufida, Niewczas, Monika A., Wong, Susan, Bassi, Roberto, D’Addio, Francesca, Schatton, Tobias, Abdi, Reza, Atkinson, Mark, Sayegh, Mohamed H., Wen, Li, Wasserfall, Clive H., O’Connor, Kevin C., Fiorina, Paolo
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2015
Предметы:
Immunology and Transplantation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274804/
https://ncbi.nlm.nih.gov/pubmed/25187361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1639
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