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Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance

Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction as a result of impaired glucose-stimulated insulin secretion (GSIS). Studies show that β-cell circadian clocks are important regulators of GSIS and glucose homeostasis. These observations raise the question about whether enhancem...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Rakshit, Kuntol, Matveyenko, Aleksey V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881843/
https://ncbi.nlm.nih.gov/pubmed/33087455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0192
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