High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus

Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer’s disease (AD). However, global cholesterol-lowering therapies have yielded mixed results when it comes to slowing down or preventing cognitive decline in AD. We used the transgenic mous...

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Publicat a:Sci Rep
Autors principals: Loera-Valencia, Raul, Vazquez-Juarez, Erika, Muñoz, Alberto, Gerenu, Gorka, Gómez-Galán, Marta, Lindskog, Maria, DeFelipe, Javier, Cedazo-Minguez, Angel, Merino-Serrais, Paula
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881004/
https://ncbi.nlm.nih.gov/pubmed/33580102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83008-3
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