27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation into the brain, reduced in vivo brain glucose uptake, GLUT4 expression, and spatial memory. Furthermore, patients ex...

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Udgivet i:J Exp Med
Main Authors: Ismail, Muhammad-Al-Mustafa, Mateos, Laura, Maioli, Silvia, Merino-Serrais, Paula, Ali, Zeina, Lodeiro, Maria, Westman, Eric, Leitersdorf, Eran, Gulyás, Balázs, Olof-Wahlund, Lars, Winblad, Bengt, Savitcheva, Irina, Björkhem, Ingemar, Cedazo-Mínguez, Angel
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339669/
https://ncbi.nlm.nih.gov/pubmed/28213512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160534
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