Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Mitochondrial pathophysiology is implicated in the development of Alzheimer’s disease (AD). An integrative database of gene dysregulation suggests that the mitochondrial ubiquitin ligase MITOL/MARCH5, a fine-tuner of mitochondrial dynamics and functions, is downregulated in patients with AD. Here, w...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Takeda, Keisuke, Uda, Aoi, Mitsubori, Mikihiro, Nagashima, Shun, Iwasaki, Hiroko, Ito, Naoki, Shiiba, Isshin, Ishido, Satoshi, Matsuoka, Masaaki, Inatome, Ryoko, Yanagi, Shigeru
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881000/
https://ncbi.nlm.nih.gov/pubmed/33580194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01720-2
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