Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Pol...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Sandusky-Beltran, Leslie A., Kovalenko, Andrii, Placides, Devon S., Ratnasamy, Kevin, Ma, Chao, Hunt, Jerry B., Liang, Huimin, Calahatian, John Ivan T., Michalski, Camilla, Fahnestock, Margaret, Blair, Laura J., Darling, April L., Baker, Jeremy D., Fontaine, Sarah N., Dickey, Chad A., Gamsby, Joshua J., Nash, Kevin R., Abner, Erin, Selenica, Maj-Linda B., Lee, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880423/
https://ncbi.nlm.nih.gov/pubmed/33586680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126299
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