Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

BACKGROUND: Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine metabolism and tau fate. Polyamines exert an array of physiol...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Sandusky-Beltran, Leslie A., Kovalenko, Andrii, Ma, Chao, Calahatian, John Ivan T., Placides, Devon S., Watler, Mallory D., Hunt, Jerry B., Darling, April L., Baker, Jeremy D., Blair, Laura J., Martin, Mackenzie D., Fontaine, Sarah N., Dickey, Chad A., Lussier, April L., Weeber, Edwin J., Selenica, Maj-Linda B., Nash, Kevin R., Gordon, Marcia N., Morgan, Dave, Lee, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599347/
https://ncbi.nlm.nih.gov/pubmed/31253191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0507-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados