Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

BACKGROUND: Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine metabolism and tau fate. Polyamines exert an array of physiol...

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Enregistré dans:
Détails bibliographiques
Publié dans:Alzheimers Res Ther
Auteurs principaux: Sandusky-Beltran, Leslie A., Kovalenko, Andrii, Ma, Chao, Calahatian, John Ivan T., Placides, Devon S., Watler, Mallory D., Hunt, Jerry B., Darling, April L., Baker, Jeremy D., Blair, Laura J., Martin, Mackenzie D., Fontaine, Sarah N., Dickey, Chad A., Lussier, April L., Weeber, Edwin J., Selenica, Maj-Linda B., Nash, Kevin R., Gordon, Marcia N., Morgan, Dave, Lee, Daniel C.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599347/
https://ncbi.nlm.nih.gov/pubmed/31253191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0507-y
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