Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

Mutant isocitrate dehydrogenase 1 (IDH1-R132H; mIDH1) is a hallmark of adult gliomas. Lower grade mIDH1 gliomas are classified into 2 molecular subgroups: 1p/19q codeletion/TERT-promoter mutations or inactivating mutations in α-thalassemia/mental retardation syndrome X-linked (ATRX) and TP53. This w...

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Pubblicato in:J Clin Invest
Autori principali: Kadiyala, Padma, Carney, Stephen V., Gauss, Jessica C., Garcia-Fabiani, Maria B., Haase, Santiago, Alghamri, Mahmoud S., Núñez, Felipe J., Liu, Yayuan, Yu, Minzhi, Taher, Ayman, Nunez, Fernando M., Li, Dan, Edwards, Marta B., Kleer, Celina G., Appelman, Henry, Sun, Yilun, Zhao, Lili, Moon, James J., Schwendeman, Anna, Lowenstein, Pedro R., Castro, Maria G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880418/
https://ncbi.nlm.nih.gov/pubmed/33332283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139542
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