Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

Mutant isocitrate dehydrogenase 1 (IDH1-R132H; mIDH1) is a hallmark of adult gliomas. Lower grade mIDH1 gliomas are classified into 2 molecular subgroups: 1p/19q codeletion/TERT-promoter mutations or inactivating mutations in α-thalassemia/mental retardation syndrome X-linked (ATRX) and TP53. This w...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kadiyala, Padma, Carney, Stephen V., Gauss, Jessica C., Garcia-Fabiani, Maria B., Haase, Santiago, Alghamri, Mahmoud S., Núñez, Felipe J., Liu, Yayuan, Yu, Minzhi, Taher, Ayman, Nunez, Fernando M., Li, Dan, Edwards, Marta B., Kleer, Celina G., Appelman, Henry, Sun, Yilun, Zhao, Lili, Moon, James J., Schwendeman, Anna, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880418/
https://ncbi.nlm.nih.gov/pubmed/33332283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139542
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