Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following congenital infection and in immunocompromised individuals. No vaccines are licensed, and there are limited treatment options. We now show that the addition of anti-HCMV antibodies (Abs) can activate NK cells p...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Vlahava, Virginia-Maria, Murrell, Isa, Zhuang, Lihui, Aicheler, Rebecca J., Lim, Eleanor, Miners, Kelly L., Ladell, Kristin, Suárez, Nicolás M., Price, David A., Davison, Andrew J., Wilkinson, Gavin W.G., Wills, Mark R., Weekes, Michael P., Wang, Eddie C.Y., Stanton, Richard J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880312/
https://ncbi.nlm.nih.gov/pubmed/33586678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139296
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