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Do haematopoietic stem cells age?

Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be responsible for age-related changes in haematopoiesis that include a decline in lymphopoiesis and skewing towards the myeloid lineage. This HSC-centric view is based largely on studies showing that HSCs from aged m...

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Dettagli Bibliografici
Pubblicato in:Nat Rev Immunol
Autori principali: Dorshkind, Kenneth, Höfer, Thomas, Montecino-Rodriguez, Encarnacion, Pioli, Peter D., Rodewald, Hans-Reimer
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879798/
https://ncbi.nlm.nih.gov/pubmed/31740804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41577-019-0236-2
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