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Synthesis of Structurally Diverse 3-, 4-, 5-, and 6-Membered Heterocycles from Diisopropyl Iminomalonates and Soft C-Nucleophiles

Herein, we present a general synthetic strategy for the preparation of 3-, 4-, 5- and 6-membered heterocyclic unnatural amino acid derivatives by exploiting facile Mannich-type reactions between readily available N-alkyl- and N-aryl-substituted diisopropyl iminomalonates and a wide range of soft ani...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Kattamuri, Padmanabha V., Bhakta, Urmibhusan, Siriwongsup, Surached, Kwon, Doo-Hyun, Alemany, Lawrence B., Yousufuddin, Muhammed, Ess, Daniel H., Kürti, László
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879484/
https://ncbi.nlm.nih.gov/pubmed/31009563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00681
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