A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

The global spread of SARS-CoV-2 is posing major public health challenges. One feature of SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit cleavage site. Here, we find that the virus with intact spike (Sfull) preferentially enters cells via fusion at the plasma m...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Zhu, Yunkai, Feng, Fei, Hu, Gaowei, Wang, Yuyan, Yu, Yin, Zhu, Yuanfei, Xu, Wei, Cai, Xia, Sun, Zhiping, Han, Wendong, Ye, Rong, Qu, Di, Ding, Qiang, Huang, Xinxin, Chen, Hongjun, Xie, Youhua, Cai, Qiliang, Yuan, Zhenghong, Zhang, Rong
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878750/
https://ncbi.nlm.nih.gov/pubmed/33574281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21213-4
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki