Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse...

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Publicat a:PLoS Pathog
Autors principals: Ren, Wenlin, Zhu, Yunkai, Wang, Yuyan, Shi, Hongyang, Yu, Yin, Hu, Gaowei, Feng, Fei, Zhao, Xiaomin, Lan, Jun, Wu, Jianping, Kenney, Devin J., Douam, Florian, Tong, Yimin, Zhong, Jin, Xie, Youhua, Wang, Xinquan, Yuan, Zhenghong, Zhou, Dongming, Zhang, Rong, Ding, Qiang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990223/
https://ncbi.nlm.nih.gov/pubmed/33760889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009392
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