Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

The SARS-CoV-2 infection is spreading rapidly worldwide. Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed. Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two Food and Drug Administration (FDA)-approved drugs, completely inhibited the cytopathic effect prod...

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Publicado no:Sci Bull (Beijing)
Main Authors: Gu, Chenjian, Wu, Yang, Guo, Huimin, Zhu, Yuanfei, Xu, Wei, Wang, Yuyan, Zhou, Yu, Sun, Zhiping, Cai, Xia, Li, Yutang, Liu, Jing, Huang, Zhong, Yuan, Zhenghong, Zhang, Rong, Deng, Qiang, Qu, Di, Xie, Youhua
Formato: Artigo
Idioma:Inglês
Publicado em: Science China Press. Published by Elsevier B.V. and Science China Press. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724564/
https://ncbi.nlm.nih.gov/pubmed/33318880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scib.2020.12.005
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