Enhanced efficacy of simultaneous PD-1 and PD-L1 immune checkpoint blockade in high grade serous ovarian cancer

Immune therapies have had limited efficacy in high grade serous ovarian cancer (HGSC), as the cellular targets and mechanism(s) of action of these agents in HGSC are unknown. Here we performed immune functional and single cell RNA-seq transcriptional profiling on novel HGSC organoid/immune cell co-c...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Wan, Changxin, Keany, Matthew P., Dong, Han, Al-Alem, Linah F., Pandya, Unnati M., Lazo, Suzan, Boehnke, Karsten, Lynch, Katherine N., Xu, Rui, Zarrella, Dominique T., Gu, Shengqing, Cejas, Paloma, Lim, Klothilda, Long, Henry W., Elias, Kevin M., Horowitz, Neil S., Feltmate, Colleen M., Muto, Michael G., Worley, Michael J., Berkowitz, Ross S., Matulonis, Ursula A., Nucci, Marisa R., Crum, Christopher P., Rueda, Bo R., Brown, Myles, Liu, Xiaole Shirley, Hill, Sarah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878408/
https://ncbi.nlm.nih.gov/pubmed/33158814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1674
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