Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

Based on genomic analysis, fifty percent of high grade serous ovarian cancers (HGSC) are predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually have functional repair defects remains unknown. Here, we devise a platform for functionally profiling DNA repair in short-t...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Discov
Egile Nagusiak: Hill, Sarah J., Decker, Brennan, Roberts, Emma A., Horowitz, Neil S., Muto, Michael G., Worley, Michael J., Feltmate, Colleen M., Nucci, Marisa R., Swisher, Elizabeth M., Nguyen, Huy, Yang, Chunyu, Morizane, Ryuji, Kochupurakkal, Bose S., Do, Khanh T., Konstantinopoulos, Panagiotis A., Liu, Joyce F., Bonventre, Joseph V., Matulonis, Ursula A., Shapiro, Geoffrey I., Berkowitz, Ross S., Crum, Christopher P., D’Andrea, Alan D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365285/
https://ncbi.nlm.nih.gov/pubmed/30213835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0474
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