Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

Based on genomic analysis, fifty percent of high grade serous ovarian cancers (HGSC) are predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually have functional repair defects remains unknown. Here, we devise a platform for functionally profiling DNA repair in short-t...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Hill, Sarah J., Decker, Brennan, Roberts, Emma A., Horowitz, Neil S., Muto, Michael G., Worley, Michael J., Feltmate, Colleen M., Nucci, Marisa R., Swisher, Elizabeth M., Nguyen, Huy, Yang, Chunyu, Morizane, Ryuji, Kochupurakkal, Bose S., Do, Khanh T., Konstantinopoulos, Panagiotis A., Liu, Joyce F., Bonventre, Joseph V., Matulonis, Ursula A., Shapiro, Geoffrey I., Berkowitz, Ross S., Crum, Christopher P., D’Andrea, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365285/
https://ncbi.nlm.nih.gov/pubmed/30213835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0474
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