CK2 Inhibits TIMELESS Nuclear Export and Modulates CLOCK Transcriptional Activity to Regulate Circadian Rhythms

Circadian clocks orchestrate daily rhythms in organismal physiology and behavior to promote optimal performance and fitness. In Drosophila, key pacemaker proteins PERIOD (PER) and TIMELESS (TIM) are progressively phosphorylated to perform phase-specific functions. Whereas PER phosphorylation has bee...

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Publicado no:Curr Biol
Main Authors: Cai, Yao D., Xue, Yongbo, Truong, Cindy C., Del Carmen-Li, Jose, Ochoa, Christopher, Vanselow, Jens T., Murphy, Katherine A., Li, Ying H., Liu, Xianhui, Kunimoto, Ben L., Zheng, Haiyan, Zhao, Caifeng, Zhang, Yong, Schlosser, Andreas, Chiu, Joanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878342/
https://ncbi.nlm.nih.gov/pubmed/33217322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.10.061
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