Monitoring of tisagenlecleucel transgene DNA using a quantitative polymerase chain reaction assay

Chimeric antigen receptor (CAR)-T cell therapies reprogram T cells to engage and eliminate cancer cells. Patients’ T cells are transduced in vitro using lentiviral or retroviral vectors containing a CAR transgene. Following infusion, CAR-T cells expand in vivo and may persist in the peripheral blood...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Davis, Lisa, Riccitelli, Nathan, Valencia, Nancy, Ch’en, Irene L., Tangri, Shabnam, Brogdon, Jennifer L., Kalfoglou, Creton, Mueller, Karen Thudium, Pollner, Reinhold
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878179/
https://ncbi.nlm.nih.gov/pubmed/33614827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.12.002
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