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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5’-methyl-thioadenosine (MTA) and L-homoserine. From environmental phages, we recen...
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| Publié dans: | eLife |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7877911/ https://ncbi.nlm.nih.gov/pubmed/33567250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61818 |
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