Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5’-methyl-thioadenosine (MTA) and L-homoserine. From environmental phages, we recen...

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Veröffentlicht in:eLife
Hauptverfasser: Guo, Xiaohu, Söderholm, Annika, Kanchugal P, Sandesh, Isaksen, Geir V, Warsi, Omar, Eckhard, Ulrich, Trigüis, Silvia, Gogoll, Adolf, Jerlström-Hultqvist, Jon, Åqvist, Johan, Andersson, Dan I, Selmer, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877911/
https://ncbi.nlm.nih.gov/pubmed/33567250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61818
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