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Enzyme surface rigidity tunes the temperature dependence of catalytic rates

The structural origin of enzyme adaptation to low temperature, allowing efficient catalysis of chemical reactions even near the freezing point of water, remains a fundamental puzzle in biocatalysis. A remarkable universal fingerprint shared by all cold-active enzymes is a reduction of the activation...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Isaksen, Geir Villy, Åqvist, Johan, Brandsdal, Bjørn Olav
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948340/
https://ncbi.nlm.nih.gov/pubmed/27354533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605237113
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