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Enzyme surface rigidity tunes the temperature dependence of catalytic rates

The structural origin of enzyme adaptation to low temperature, allowing efficient catalysis of chemical reactions even near the freezing point of water, remains a fundamental puzzle in biocatalysis. A remarkable universal fingerprint shared by all cold-active enzymes is a reduction of the activation...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Isaksen, Geir Villy, Åqvist, Johan, Brandsdal, Bjørn Olav
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948340/
https://ncbi.nlm.nih.gov/pubmed/27354533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605237113
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