Effect of SLCO1B1 Polymorphisms on High‐Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma

High‐dose (HD) methotrexate (MTX) is a critical component of treatment for hematologic malignancies in children and young adults. Therapeutic drug monitoring is necessary due to substantial interindividual variation in MTX clearance. Common function‐altering polymorphisms in SLCO1B1 (encodes OATP1B1...

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Udgivet i:Clin Transl Sci
Main Authors: Schulte, Rachael R., Choi, Leena, Utreja, Nipun, Van Driest, Sara L., Stein, C. Michael, Ho, Richard H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877862/
https://ncbi.nlm.nih.gov/pubmed/32961024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12879
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