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High-Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia: Predictors of Delayed Clearance and the Effect of Increased Hydration Rate on Methotrexate Clearance

Objectives High-dose methotrexate (HDMTX) is an important chemotherapeutic agent in the treatment of many cancers. Identification of the predictors of poor clearance during HDMTX infusions could advance the introduction of improved supportive care to prevent toxicities and reduce hospital length of...

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Detalhes bibliográficos
Publicado no:Cureus
Main Authors: Chen, Aaron R, Wang, YunZu M, Lin, Mark, Kuo, Dennis J
Formato: Artigo
Idioma:Inglês
Publicado em: Cureus 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370657/
https://ncbi.nlm.nih.gov/pubmed/32699674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7759/cureus.8674
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