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Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

The circadian clock drives extensive temporal gene expression programs controlling daily changes in behavior and physiology. In mouse liver, transcription factors dynamics, chromatin modifications, and RNA Polymerase II (PolII) activity oscillate throughout the 24-hour (24h) day, regulating the rhyt...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Mermet, Jérôme, Yeung, Jake, Naef, Felix
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877755/
https://ncbi.nlm.nih.gov/pubmed/33524027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009350
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