JNK1 ablation improves pancreatic β‐cell mass and function in db/db diabetic mice without affecting insulin sensitivity and adipose tissue inflammation

The cJun N‐terminal Kinases (JNK) emerged as a major link between obesity and insulin resistance, but their role in the loss of pancreatic β‐cell mass and function driving the progression from insulin resistance to type‐2 diabetes and in the complications of diabetes was not investigated to the same...

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Veröffentlicht in:FASEB Bioadv
Hauptverfasser: Mazzoli, Arianna, Sardi, Claudia, Breasson, Ludovic, Theilig, Franziska, Becattini, Barbara, Solinas, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876705/
https://ncbi.nlm.nih.gov/pubmed/33615154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2020-00081
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