JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage

Obesity and insulin resistance are associated with oxidative stress, which may be implicated in the progression of obesity-related diseases. The kinase JNK1 has emerged as a promising drug target for the treatment of obesity and type 2 diabetes. JNK1 is also a key mediator of the oxidative stress re...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Becattini, Barbara, Zani, Fabio, Breasson, Ludovic, Sardi, Claudia, D'Agostino, Vito Giuseppe, Choo, Min-Kyung, Provenzani, Alessandro, Park, Jin Mo, Solinas, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191003/
https://ncbi.nlm.nih.gov/pubmed/27230858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600393R
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