Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key component of PI3K signaling pathway, manifest a reduced skeletal...

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Vydáno v:Sci Rep
Hlavní autoři: Kuramoto, Naoki, Nomura, Kazuhiro, Kohno, Daisuke, Kitamura, Tadahiro, Karsenty, Gerard, Hosooka, Tetsuya, Ogawa, Wataru
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876046/
https://ncbi.nlm.nih.gov/pubmed/33568757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83098-z
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