Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PYK2, is sorted into exosomes by HSP90 via its KFERQ...

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Pubblicato in:Signal Transduct Target Ther
Autori principali: Zhong, Li, Liao, Dan, Li, Jingjing, Liu, Wenqiang, Wang, Jingxuan, Zeng, Cuiling, Wang, Xin, Cao, Zhiliang, Zhang, Ruhua, Li, Miao, Jiang, Kuntai, Zeng, Yi-Xin, Sui, Jianhua, Kang, Tiebang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876000/
https://ncbi.nlm.nih.gov/pubmed/33568623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00414-1
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