Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed in osteosarcoma cell lines and tissues. CBX4 promoted metastasis by transcriptionally up-regulating Runx2 via the recruitmen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Xin, Qin, Ge, Liang, Xiaoting, Wang, Wen, Wang, Zhuo, Liao, Dan, Zhong, Li, Zhang, Ruhua, Zeng, Yi-Xin, Wu, Yuanzhong, Kang, Tiebang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048933/
https://ncbi.nlm.nih.gov/pubmed/32111827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14870-4
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