Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels

Despite potently inhibiting the nociceptive voltage-gated sodium (Na(v)) channel, Na(v)1.7, µ-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Na(v)1.7 IC (50) by a yet undefined mechanism. N...

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Bibliografiska uppgifter
I publikationen:Front Pharmacol
Huvudupphovsmän: McArthur, Jeffrey R., Munasinghe, Nehan R., Finol-Urdaneta, Rocio K., Adams, David J., Christie, Macdonald J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875911/
https://ncbi.nlm.nih.gov/pubmed/33584315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.633679
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