Prevention of anastomotic leak via local application of tranexamic acid to target bacterial-mediated plasminogen activation: a practical solution to a complex problem.

OBJECTIVE: To investigate the role of bacterial- mediated plasminogen activation in the pathogenesis of anastomotic leak (AL) and its mitigation by tranexamic acid. SUMMARY BACKGROUND DATA: AL is the most feared complication of colorectal resections. The pathobiology of AL in the setting of a techni...

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Detalhes bibliográficos
Publicado no:Ann Surg
Main Authors: Jacobson, Richard A, Williamson, Ashley, Wienholts, Kiedo, Gaines, Sara, Hyoju, Sanjiv, van Goor, Harry, Zaborin, Alexander, Shogan, Benjamin D., Zaborina, Olga, Alverdy, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875208/
https://ncbi.nlm.nih.gov/pubmed/31851007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0000000000003733
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