Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin

Transforming growth factor β (TGF-β) has been shown to promote tumor invasion and metastasis by activating the matrix metalloproteinases (MMPs); however, signaling mechanisms remain controversial and therapies targeting MMPs are still suboptimal. In the present study, we found that combined therapy...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: Lian, Guang-Yu, Wang, Qing-Ming, Mak, Thomas Shiu-Kwong, Huang, Xiao-Ru, Yu, Xue-Qing, Lan, Hui-Yao
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873580/
https://ncbi.nlm.nih.gov/pubmed/33614911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2021.01.006
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