Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in coronaviruses. As endoribonuclease activity seems to be responsible for the interference with the innate immune response, Nsp15 emerges as an attractive...

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Vydáno v:Commun Biol
Hlavní autoři: Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873276/
https://ncbi.nlm.nih.gov/pubmed/33564093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01735-9
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