Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in coronaviruses. As endoribonuclease activity seems to be responsible for the interference with the innate immune response, Nsp15 emerges as an attractive...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873276/
https://ncbi.nlm.nih.gov/pubmed/33564093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01735-9
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