Site-Directed Mutagenesis of the Nidovirus Replicative Endoribonuclease NendoU Exerts Pleiotropic Effects on the Arterivirus Life Cycle

The highly conserved NendoU replicative domain of nidoviruses (arteriviruses, coronaviruses, and roniviruses) belongs to a small protein family whose cellular branch is prototyped by XendoU, a Xenopus laevis endoribonuclease involved in nucleolar RNA processing. Recently, sequence-specific in vitro...

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Bibliographic Details
Main Authors: Posthuma, Clara C., Nedialkova, Danny D., Zevenhoven-Dobbe, Jessika C., Blokhuis, Jeroen H., Gorbalenya, Alexander E., Snijder, Eric J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367138/
https://ncbi.nlm.nih.gov/pubmed/16439522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.1653-1661.2006
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