Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive pediatric glioma had reduced H3K36 trimethylation and...

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Опубликовано в: :eLife
Главные авторы: Lowe, Brandon R, Yadav, Rajesh K, Henry, Ryan A, Schreiner, Patrick, Matsuda, Atsushi, Fernandez, Alfonso G, Finkelstein, David, Campbell, Margaret, Kallappagoudar, Satish, Jablonowski, Carolyn M, Andrews, Andrew J, Hiraoka, Yasushi, Partridge, Janet F
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Chromosomes and Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872514/
https://ncbi.nlm.nih.gov/pubmed/33522486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65369
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