Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive pediatric glioma had reduced H3K36 trimethylation and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Lowe, Brandon R, Yadav, Rajesh K, Henry, Ryan A, Schreiner, Patrick, Matsuda, Atsushi, Fernandez, Alfonso G, Finkelstein, David, Campbell, Margaret, Kallappagoudar, Satish, Jablonowski, Carolyn M, Andrews, Andrew J, Hiraoka, Yasushi, Partridge, Janet F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Chromosomes and Gene Expression
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872514/
https://ncbi.nlm.nih.gov/pubmed/33522486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65369
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