Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission y...

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Vydáno v:eLife
Hlavní autoři: Yadav, Rajesh K, Jablonowski, Carolyn M, Fernandez, Alfonso G, Lowe, Brandon R, Henry, Ryan A, Finkelstein, David, Barnum, Kevin J, Pidoux, Alison L, Kuo, Yin-Ming, Huang, Jie, O’Connell, Matthew J, Andrews, Andrew J, Onar-Thomas, Arzu, Allshire, Robin C, Partridge, Janet F
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Genes and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515577/
https://ncbi.nlm.nih.gov/pubmed/28718400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27406
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