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Mining Natural Products for Macrocycles to Drug Difficult Targets
[Image: see text] Lead generation for difficult-to-drug targets that have large, featureless, and highly lipophilic or highly polar and/or flexible binding sites is highly challenging. Here, we describe how cores of macrocyclic natural products can serve as a high-quality in silico screening library...
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| Veröffentlicht in: | J Med Chem |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2020
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7872424/ https://ncbi.nlm.nih.gov/pubmed/33337880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01569 |
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