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Mining Natural Products for Macrocycles to Drug Difficult Targets

[Image: see text] Lead generation for difficult-to-drug targets that have large, featureless, and highly lipophilic or highly polar and/or flexible binding sites is highly challenging. Here, we describe how cores of macrocyclic natural products can serve as a high-quality in silico screening library...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Begnini, Fabio, Poongavanam, Vasanthanathan, Over, Björn, Castaldo, Marie, Geschwindner, Stefan, Johansson, Patrik, Tyagi, Mohit, Tyrchan, Christian, Wissler, Lisa, Sjö, Peter, Schiesser, Stefan, Kihlberg, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872424/
https://ncbi.nlm.nih.gov/pubmed/33337880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01569
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