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Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
[Image: see text] Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme which regulates the methylation of Lys4 of histone 3 (H3) and is overexpressed in certain cancers. We used structures of H3 substrate analogues bound to LSD1 to design macrocyclic peptide inhibitors of LSD1. A linear, Lys...
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| Wydane w: | ACS Omega |
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| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2020
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057333/ https://ncbi.nlm.nih.gov/pubmed/32149225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03493 |
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