Immune evasive human islet-like organoids ameliorate diabetes

While stem cell-derived islets hold promise as a therapy for insulin-dependent diabetes, challenges remain in achieving this goal(1–6). Here we generate human islet-like organoids (HILOs) from induced pluripotent stem cells (iPSCs) and show that non-canonical WNT4 signaling drives the metabolic matu...

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Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Yoshihara, Eiji, O’Connor, Carolyn, Gasser, Emanuel, Wei, Zong, Oh, Tae Gyu, Tseng, Tiffany W., Wang, Dan, Cayabyab, Fritz, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, Evans, Ronald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872080/
https://ncbi.nlm.nih.gov/pubmed/32814902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2631-z
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