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A-to-I RNA editing of Alu dsRNAs is markedly decreased in MS; unedited Alu dsRNAs but not edited Alu dsRNAs are potent activators of pro-inflammatory transcriptional responses

Sensors that detect double stranded RNA stimulate IFN-responses as a defense against viral infection. IFN-responses are also well documented in a variety of human autoimmune diseases including relapsing remitting multiple sclerosis in which increased IFN-responses result from increased levels of dou...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Tossberg, John T., Heinrich, Rachel M., Farley, Virginia M., Crooke, Philip S., Aune, Thomas M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872017/
https://ncbi.nlm.nih.gov/pubmed/33046502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000384
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