YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge as two important signaling pathways downstream of G protein alpha subunits of the Q class (GαQ/11)-mediated transformation, although whether...

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Udgivet i:Cell Rep
Main Authors: Li, Huapeng, Li, Qi, Dang, Kyvan, Ma, Shan, Cotton, Jennifer L., Yang, Sun, Zhu, Lihua J., Deng, April C., Ip, Y. Tony, Johnson, Randy L., Wu, Xu, Punzo, Claudio, Mao, Junhao
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871510/
https://ncbi.nlm.nih.gov/pubmed/31801083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.021
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