Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice

BACKGROUND: The neuropathological hallmarks of Alzheimer’s disease (AD) are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). The amyloid cascade theory is the leading hypothesis of AD pathology. Aβ deposition precedes the aggregation of tau pathology and Aβ pathology precipitates tau patho...

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Bibliographic Details
Published in:	Alzheimers Res Ther
Main Authors:	Chen, Yanxing, Zhao, Shuai, Fan, Ziqi, Li, Zheyu, Zhu, Yueli, Shen, Ting, Li, Kaicheng, Yan, Yaping, Tian, Jun, Liu, Zhirong, Zhang, Baorong
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2021
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7871393/ https://ncbi.nlm.nih.gov/pubmed/33563332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00761-9
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Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice

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