Effects of the Tobacco Carcinogens N′‑Nitrosonornicotine and Dibenzo[a,l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue

In previous studies, we showed that the topical application of dibenzo[a,l]pyrene (DB[a,l]P), also known as dibenzo[def,p]chrysene, to the oral cavity of mice induced oral squamous cell carcinoma. We also showed that dA and dG adducts likely account for most of the mutagenic activity of DB[a,l]P in...

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Détails bibliographiques
Publié dans:Chem Res Toxicol
Auteurs principaux: Guttenplan, Joseph B., Chen, Kun-Ming, Sun, Yuan-Wan, Shalaby, Nora A. E., Kosinska, Wieslawa, Desai, Dhimant, Gowda, Krishne, Amin, Shantu, El-Bayoumy, Karam
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7871194/
https://ncbi.nlm.nih.gov/pubmed/31433626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00257
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